Beta-Amyloid(25-35) CAS 131602-53-4
Identification
CAS Number
131602-53-4
Name
Beta-Amyloid(25-35)
Peptide sequence
Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met
Synonyms
131602-53-4 [RN]
amyloid β-peptide(25-35)
Glycyl-L-seryl-L-asparaginyl-L-lysylglycyl-L-alanyl-L-isoleucyl-L-isoleucylglycyl-L-leucyl-L-methionin [German] [ACD/IUPAC Name]
Glycyl-L-seryl-L-asparaginyl-L-lysylglycyl-L-alanyl-L-isoleucyl-L-isoleucylglycyl-L-leucyl-L-methionine [ACD/IUPAC Name]
Glycyl-L-séryl-L-asparaginyl-L-lysylglycyl-L-alanyl-L-isoleucyl-L-isoleucylglycyl-L-leucyl-L-méthionine [French] [ACD/IUPAC Name]
L-Methionine, glycyl-L-seryl-L-asparaginyl-L-lysylglycyl-L-alanyl-L-isoleucyl-L-isoleucylglycyl-L-leucyl- [ACD/Index Name]
(2S)-2-[[(2S)-2-[[2-[[(2S,3S)-2-[[(2S,3S)-2-[[(2S)-2-[[2-[[(2S)-6-amino-2-[[(2S)-4-amino-2-[[(2S)-2-[(2-aminoacetyl)amino]-3-hydroxypropanoyl]amino]-4-oxobutanoyl]amino]hexanoyl]amino]acetyl]amino]propanoyl]amino]-3-methylpentanoyl]amino]-3-methylpentanoyl]amino]acetyl]amino]-4-methylpentanoyl]amino]-4-methylsulfanylbutanoic acid
[131602-53-4]
Å-Amyloid (25-35)
Amyloid b (25-35)
Amyloid β-peptide (25-35) (human)
Amyloid-�� Peptide (25-35), Human
Amyloid β Protein fragment 25-35
Amyloid β-peptide (25-35) (human)
amyloid β-protein (25-35)
amyloid β-protein fragment 25-35
amyloidβpeptide(25-35),human
BU7435200
Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met
H-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-OH
L-Methionine,glycyl-L-seryl-L-asparaginyl-L-lysylglycyl-L-alanyl-L-isoleucyl-L-isoleucylglycyl-L-leucyl-
MFCD00133076
β-AMYLOID (25-35)
SMILES
CC[C@H](C)[C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)O)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CO)NC(=O)CN
StdInChI
InChI=1S/C45H81N13O14S/c1-9-24(5)36(43(69)50-21-35(63)52-29(17-23(3)4)40(66)55-28(45(71)72)14-16-73-8)58-44(70)37(25(6)10-2)57-38(64)26(7)51-34(62)20-49-39(65)27(13-11-12-15-46)54-41(67)30(18-32(48)60)56-42(68)31(22-59)53-33(61)19-47/h23-31,36-37,59H,9-22,46-47H2,1-8H3,(H2,48,60)(H,49,65)(H,50,69)(H,51,62)(H,52,63)(H,53,61)(H,54,67)(H,55,66)(H,56,68)(H,57,64)(H,58,70)(H,71,72)/t24-,25-,26-,27-,28-,29-,30-,31-,36-,37-/m0/s1
StdInChIKey
WIHBNMPFWRHGDF-SLVFWPMISA-N
Molecular Formula
C45H81N13O14S
Molecular Weight
1060.27
MDL Number
MFCD00133076
Properties
Appearance
White powder
Safety Data
Personal Protective Equipment
dust mask type N95 (US),Eyeshields,Gloves
RIDADR
NONH for all modes of transport
WGK Germany
3
Specifications and Other Information of Our Beta-Amyloid(25-35) CAS 131602-53-4
Identification Methods
HNMR, HPLC
Purity
98% min
Absorption coefficient
0 M-1cm-1
PI,isoelectric point
pH 10.12
Net charge at pH 7
1
Toxicity mechanism of Amyloid oligomer
- The effect on oxidative stress. Aβ can induce oxidative stress, produce a large number of free radicals, and then produce oxidative stress on neurons.
- Cause Ca2+ disorder. Aβ destroys the K+ channel on the cell membrane, causing a large amount of Ca2+ influx.
- Interaction with receptors on the cell membrane surface. Amyloid oligomers can activate excitatory NMDA2RS receptors, causing mitochondrial disorders and neuronal death.
- Amyloid in cells is also an important pathological feature. A large number of oligomers in the cells cause pathology. The production and degradation of Amyloid secreted by normal cells is relatively balanced.
- Break the balance between Bax and Bel-2.
Solubility evaluation
Poor water solubility
Shelf Life
2 years
Storage
Store at -20°C or -80°C for long time, Sealed and away from light
Known Application
Often used to study Alzheimer’s disease.