Buserelin CAS 68630-75-1
Identification
CAS Number
68630-75-1
Name
Buserelin
Synonyms
5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-O-(2-methyl-2-propanyl)-D-seryl-L-leucyl-L-arginyl-N-ethyl-L-prolinamidacetat (1:1) [German] [ACD/IUPAC Name]
5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-O-(2-methyl-2-propanyl)-D-seryl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide acetate (1:1) [ACD/IUPAC Name]
5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-O-tert-butyl-D-seryl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide acetate (1:1)
68630-75-1 [RN]
Acide acétique – 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-séryl-L-tyrosyl-O-(2-méthyl-2-propanyl)-D-séryl-L-leucyl-L-arginyl-N-éthyl-L-prolinamide (1:1) [French] [ACD/IUPAC Name]
Buserelin acetate [JAN] [USAN]
Buserelin monoacetate
HOE 766MP {Acetate}
L-Prolinamide, 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-O-(1,1-dimethylethyl)-D-seryl-L-leucyl-L-arginyl-N-ethyl-, acetate (1:1) [ACD/Index Name]
(Des-Gly10,D-Ser(tBu)6,Pro-NHEt9)-LHRH
(S)-1-((3S,6S,9S,12S,15R,18S,21S)-3-((1H-imidazol-5-yl)methyl)-6-((1H-indol-3-yl)methyl)-15-(tert-butoxymethyl)-21-(3-((diaminomethylene)amino)propyl)-12-(4-hydroxybenzyl)-9-(hydroxymethyl)-18-isobutyl-1,4,7,10,13,16,19-heptaoxo-1-((S)-5-oxopyrrolidin-2-yl)-2,5,8,11,14,17,20-heptaazadocosan-22-oyl)-N-ethylpyrrolidine-2-carboxamide acetate
[68630-75-1]
1-9-Luteinizing hormone-releasing factor (swine), 6-[O-(1,1- dimethylethyl)-D-serine]-9-(N-ethyl-L-prolinamide)-, monoacetate (salt)
261-061-9 [EINECS]
57982-77-1 [RN]
5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-O-tert-butyl-D-seryl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide monoacetate (salt)
Buserelin acetate (JAN/USAN) [JAN] [USAN]
HOE 766 MP
Hoe-766 MP
MFCD00870371 [MDL number]
MFCD01716229
Suprecur [Trade name]
Suprefact
SMILES
CCNC(=O)[C@@H]1CCCN1C(=O)[[email protected]](CCCNC(=N)N)NC(=O)[[email protected]](CC(C)C)NC(=O)[C@@H](COC(C)(C)C)NC(=O)[[email protected]](Cc2ccc(cc2)O)NC(=O)[[email protected]](CO)NC(=O)[[email protected]](Cc3c[nH]c4c3cccc4)NC(=O)[[email protected]](Cc5cnc[nH]5)NC(=O)[C@@H]6CCC(=O)N6.CC(=O)O
StdInChI
InChI=1S/C60H86N16O13.C2H4O2/c1-7-64-57(87)48-15-11-23-76(48)58(88)41(14-10-22-65-59(61)62)69-51(81)42(24-33(2)3)70-56(86)47(31-89-60(4,5)6)75-52(82)43(25-34-16-18-37(78)19-17-34)71-55(85)46(30-77)74-53(83)44(26-35-28-66-39-13-9-8-12-38(35)39)72-54(84)45(27-36-29-63-32-67-36)73-50(80)40-20-21-49(79)68-40;1-2(3)4/h8-9,12-13,16-19,28-29,32-33,40-48,66,77-78H,7,10-11,14-15,20-27,30-31H2,1-6H3,(H,63,67)(H,64,87)(H,68,79)(H,69,81)(H,70,86)(H,71,85)(H,72,84)(H,73,80)(H,74,83)(H,75,82)(H4,61,62,65);1H3,(H,3,4)/t40-,41-,42-,43-,44-,45-,46-,47+,48-;/m0./s1
StdInChIKey
PYMDEDHDQYLBRT-DRIHCAFSSA-N
Molecular Formula
C62H90N16O15
Molecular Weight
1299.47
MDL Number
MFCD00941414
Properties
Appearance
White or slightly yellowish powder
Safety Data
Symbol
GHS07,GHS08Signal Word
Danger
Hazard statements
H302 – H360Precautionary Statements
P201 – P301 + P312 + P330 – P308 + P313Personal Protective Equipment
Eyeshields, Faceshields, Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
RIDADR
NONH for all modes of transport
WGK Germany
3
Specifications and Other Information of Our Buserelin CAS 68630-75-1
Identification Methods
HPLC
Assay
95%~102%
Specific Optical Rotation
-49.0 ～ -58.0°[a] 20 D (c=1, water)
Specific Absorbance(By anhydrous, acetic acid-free)
49~56(278nm)
Water
≤4.0%
Amino Acid Composition
| Arg | 0.9 ～ 1.1 |
| Leu | 0.9 ～ 1.1 |
| Tyr | 0.9 ～ 1.1 |
| Glu | 0.9 ～ 1.1 |
| Pro | 0.8 ～ 1.2 |
| His | 0.9 ～ 1.1 |
| Ser | 1.4 ～ 2.0 |
| Trp | Detected |
Related Substance (By HPLC)
Single Impurity
≤1.0%
Total Impurities
≤5.0%
Acetate Content (By HPLC)
3~7%
Bacterial Endotoxins
≤55.5 IU/mg
Shelf Life
2 years
Storage
Store at 2~8℃, sealed and away from light.
Known Application
It is often used to treat prostate cancer, breast cancer, endometriosis, uterine fibroids and other diseases. The clinical dosage forms are injections and nasal sprays.