IGF-1 CAS 67763-96-6
Identification
Properties
Safety Data
Specifications
Links
Identification
Name
IGF-1
CAS Number
67763-96-6, 61461-67-4
Synonyms
Insulin-Like Growth Factor-I, Human
Insulin Growth Factor-I, Human
SM-C
Somatomedin 1
IGF-A, Human
Sulfation Factor C
Myotrophin
rhIGF-I
Insulin-likegrowth factor I
MDL Number
MFCD00081716
Properties
Appearance
Lyophilized Powder
Recombinant
Expressed in E. coli
Safety Data
Personal Protective Equipment
Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
WGK Germany
3
Specifications and Other Information of Our IGF-1 CAS 67763-96-6
Volume
1±0.1mg/vial
Concentration
1.01mg/ml
Specific Activity
80000IU/mg
Identification Methods
Electrophoresis, HPLC
Purity
97%
Impurity Peak(10.1’)
1.5%
Impurity Peak(11.3’)
1.5%
Sterility
Sterile-filtered
Endotoxin
4EU/mg
Related Substances
1% max
Analysis Note
The biological activiy is calculated by the dose-dependent proliferation of murine BALB/C3T3 cells. ED50 corresponds to a specific activity of at least 1 x 107 units/mg.
Reconstitution
Reconstitute in water.
Physical Form
Lyophilized from 0.2 μm filtered solution in 50 mM acetic acid.
Biochem/physiol Actions
IGF-1 belongs to the insulin-like growth factor family of signaling molecules that play critical roles in cellular energy metabolism and in growth and development, especially prenatal growth.Also known as somatomedin C, is secreted from the liver into circulation in a process regulated by pituitary growth hormone (GH) and so it mediates the growth-promoting activity of GH. In the developing embryo IGF-I is expressed primarily by mesenchymal-derived cells. After birth IGF-I expression in most extrahepatic tissues declines and hepatic expression of it becomes GH-regulated. Expression of IGF-I outside the liver is regulated differently, depending on the specific tissues. For example, gonadotropins and sex steroids regulate IGF-I expression within the reproductive system, while parathyroid hormone and sex steroids regulate IGF-I expression in bone. It is produced in several human tumors. It is mitogenic for a variety of cells including fibroblasts, osteoblasts, smooth muscle cells, fetal brain cells, neuroglial cells, and erythroid progenitor cells. IGF-I exerts its actions exclusively through the IGF-I receptor (IGF-IR). it induces endothelial cell migration and is involved in the regulation of angiogenesis.
Also known as somatomedin C, is secreted from the liver into circulation in a process regulated by pituitary growth hormone (GH) and so it mediates the growth-promoting activity of GH. In the developing embryo it is expressed primarily by mesenchymal-derived cells. After birth IGF-I expression in most extrahepatic tissues declines and hepatic expression of it becomes GH-regulated. Expression of IGF-I outside the liver is regulated differently, depending on the specific tissues. For example, gonadotropins and sex steroids regulate IGF-I expression within the reproductive system, while parathyroid hormone and sex steroids regulate IGF-I expression in bone. It is produced in several human tumors. IGF-I is mitogenic for a variety of cells including fibroblasts, osteoblasts, smooth muscle cells, fetal brain cells, neuroglial cells, and erythroid progenitor cells. It exerts its actions exclusively through the IGF-I receptor (IGF-IR). It induces endothelial cell migration and is involved in the regulation of angiogenesis.
General View of Documents
IGF-1 CAS 67763-96-6 Electrophoresis
Storage
−20°C
Links
Watson-Int Link
http://watson-int.com/IGF-1_CAS_67763-96-6.html