custom synthesis

Custom Synthesis Service

Amino Acids



Custom Synthesis Service

Although A.P.Noke offers more than 4000 amino acids, peptides and other related products available from stock, your project may require a product not listed in our catalogue.
Then contact our custom synthesis team and ask for an offer. Let our experienced scientists prepare the exact product you need.

  • Expertise: Our chemists can prepare compounds according to your specifications in any scale you need – from milligram to kilogram and ton quantities. We are experts in producing complicated amino acids and long and difficult peptides.
  • Quality: A.P.Noke is committed to using synthesis and purification strategies that yield products of the quality and purity you require. Our standard analytical package typically includes mass spectrometric analysis, amino acid analysis, and determination of purity (by RP-HPLC) and peptide content. A.P.Noke sets industry standards for high quality custom synthesis.
  • Efficient service: Our custom synthesis techniques in combination with high capacity and state-of-the-art production equipment allow short delivery times without compromising quality. You will get technical support with the design of your products and complex organic molecules. If you need a custom amino acid or peptide, please challenge us with your ideas and take advantage of our expertise.

Amino Acids

A.P.Noke has rich experience in research and manufacture of amino acids and their derivatives. Include Natural Amino Acids, Unnatural Amino Acids, Amino Alcohols, N-Methyl Amino Acids, Phosphorylated Amino Acids etc.

Our advantage

  • Specialty. Rich experience in synthesis and resolution of amino acids
  • High grade. Effect quality control by NMR、HPLC、EE.、Optical Rotation etc.
  • Reasonable price. Mature product line with the industrialization of the production process allows us to control costs effectively and offer you the best price.
  • In time. Different levels of  intermediate inventory enable us to meet your needs quickly.

amino acid


We Offer: High quality peptides made by experts & delivered to you with all documents:

  • HPLC chromatogram
  • Mass spec analysis
  • Synthesis report

Range of Services:
Our staffs are experienced in the synthesis of high quality peptides with various modifications. With over 200 units of analytical and preparative HPLC, we can provide peptides from small scale (mgs) to large scale (kgs) in very fast delivery:

  • Simple to complex and Linear to cyclized
  • Long sequences peptide up to 140 mer
  • From small to large scale
  • Different purity level (desalted, >75%, >85%, >90%, >95%, >98% and even above 99%)
  • Widest variety of modifications (from biotinylation to phosphorylation, to dye labeling, and much more…)
  • Peptides – Protein Bioconjugation
  • Purification at different scales
  • Highest success rate in the industry

List of Modification

N,C-terminal  ModificationSpecial Amino acidFluorescence/Dye labelingCyclic PeptideQuenched Fluorescent PeptideMultiple Antigenic Peptide SystemProtein Conjugation
Acetylation (N-Terminal),D-Arg, D-Cys, D-Asp, D-Asn, D-Glu, D-Gln, D-Ser, D-His, D-Thr, D-Trp, D-Leu,D-Ile, D-Met, D-Pro, D-Val ,D-Phe, pGlu, Hyp, D-Lys,D-Tyr, D-Orn, Orn, Abu, Aib, (D)1-Nal, (D)2-Pal, (D)4-Cl-Phe, Nva, Nle, Hse, Hcy, Pen, Mpa,N-Methyl amino acid (Ala, Phe, Leu, Ile, Val, Gly, Met),Other amino acid, Dinitrobenzoylation (Lys), Lys(Me2), Phosphorylation (Tyr, Ser, Thr, single site), Tyr(SO3H2), Ser(octanoic acid)Biotin (N-Terminal, Y/N Ahx),Disulfide bridge 1stAbz/ Tyr (3-NO2),Asymmetric 4 branchesKLH
HYNIC (N-Terminal),Biotin (Lys in sequence)Disulfide bridge 2ndEDANS/DABCYLAsymmetric 8 branchesBSA
DTPA (N-Terminal),Biotin (without Lys in sequence)Disulfide bridge 3rd
Formylation (N-Terminal)FITC/5-FAM (N-Terminal, Y/N Ahx)Amide cyclic (Side chain, end)
Fatty acid (N-Terminal)Dansyl (N-Terminal, Y/N Ahx)
Myristic acid (N-Terminal)MCA (N-Terminal)
Palmytolyl (N-Terminal)p-Nitroanilide(pNA, C-Terminal)
Benzyloxycarbonylation (CBZ)AMC (C-Terminal)
Amidation (C-Terminal)
Succinylation (Suc, N-Terminal)