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Tetracosactide Acetate CAS 16960-16-0

Tetracosactide Acetate CAS 16960-16-0

In Key Products, Peptide, Products

Identification
Properties
Safety Data
Specifications & Other Information
Links

Identification

CAS Number

16960-16-0

Name

Tetracosactide Acetate

Sequence

Ser-Tyr-Ser-Met-Glu-His-Phe- Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys- Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr- Pro

Synonyms

16960-16-0 [RN]
Cortrosyn [Trade name]
cosyntropin [USAN]
L-Proline, L-seryl-L-tyrosyl-L-seryl-L-methionyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valylglycyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-prolyl-L-v
alyl-L-lysyl-L-valyl-L-tyrosyl- [ACD/Index Name]
L-proline, L-seryl-L-tyrosyl-L-seryl-L-methionyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valylglycyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-prolyl-L-valyl-L-lysyl-L-valyl-L-tyrosyl-
L-seryl-L-tyrosyl-L-seryl-L-methionyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valylglycyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-prolyl-L-valyl-L-lysy
L-Seryl-L-tyrosyl-L-seryl-L-methionyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valylglycyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-prolyl-L-valyl-L-lysy
l-L-valyl-L-tyrosyl-L-prolin [German] [ACD/IUPAC Name]
L-Seryl-L-tyrosyl-L-seryl-L-methionyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valylglycyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-prolyl-L-valyl-L-lysy
l-L-valyl-L-tyrosyl-L-proline [ACD/IUPAC Name]
L-Séryl-L-tyrosyl-L-séryl-L-méthionyl-L-α-glutamyl-L-histidyl-L-phénylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valylglycyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-prolyl-L-valyl-L-lysy
l-L-valyl-L-tyrosyl-L-proline [French] [ACD/IUPAC Name]
L-Seryl-L-tyrosyl-L-seryl-L-methionyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valylglycyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-prolyl-L-valyl-L-lysyl-L-valyl-L-tyrosyl-L-proline
Porcine ACTH (1-24)
tetracosactida [Spanish] [INN]
Tetracosactide [INN] [Wiki]
tétracosactide [French] [INN]
tetracosactidum [Latin] [INN]
y-29-(4-hydroxybenzyl)-26-(hydroxymethyl)-17-(1H-imidazol-4-ylmethyl)-8-(1H-indol-3-ylmethyl)-23-[2-(methylsulfanyl)ethyl]-4,7,10,13,16,19,22,25,28,31-decaoxo-3,6,9,12,15,18,21,24,27,30-decaazatritria
α1-24-Corticotropin
тетракозактид [Russian] [INN]
تيتراكوساكتيد [Arabic] [INN]
替可克肽 [Chinese] [INN]
??1-24-corticotrophin
[16960-16-0]
a1-24-Corticotropin
ACTH (1-24) (human, bovine, rat)
ACTH (1-24), Human
ACTH(1-24)
Actholain
Adrenocorticotropic hormone 1-24
Adrenocorticotropic hormone fragment 1-24 human, rat
ATCH (1-24)
Corticotropin tetracosapeptide
Corticotropin-(1-24)
corticotropin-(1-24) tetracosapeptide
Cortrophin S
L-seryl-L-tyrosyl-L-seryl-L-methionyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valylglycyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-prolyl-L-valyl-L-lysyl-L-valyl-L-tyrosyl-L-prolyline
MFCD00167476 [MDL number]
SerTyrSerMetGluHisPheArgTrpGlyLysProValGlyLysLysArgArgProValLysValTyrPro
Synacthene-retard
SYSMEHFRWGKPVGKKRRPVKVYP
Tetracosactid
tetracosactrin
Tetracosapeptide
α(1-24)-corticotrophin
β(1-24)-corticotrophin

SMILES

CC(C)[C@@H](C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)N3CCC[C@H]3C(=O)O)NC(=O)[C@@H]4CCCN4C(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CC5=CNC6=CC=CC=C65)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC7=CC=CC=C7)NC(=O)[C@H](CC8=CN=CN8)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CO)NC(=O)[C@H](CC9=CC=C(C=C9)O)NC(=O)[C@H](CO)N

StdInChI

InChI=1S/C136H210N40O31S/c1-75(2)109(127(200)154-71-106(181)156-88(31-13-17-52-137)114(187)158-89(32-14-18-53-138)115(188)159-91(35-21-56-149-134(142)143)116(189)164-96(37-23-58-151-136(146)147)131(204)175-60-25-39-104(175)126(199)173-111(77(5)6)128(201)163-90(33-15-19-54-139)120(193)171-110(76(3)4)129(202)169-101(65-80-43-47-84(180)48-44-80)132(205)176-61-26-40-105(176)133(206)207)172-125(198)103-38-24-59-174(103)130(203)95(34-16-20-55-140)157-107(182)70-153-113(186)99(66-81-68-152-87-30-12-11-29-85(81)87)167-117(190)92(36-22-57-150-135(144)145)160-121(194)98(63-78-27-9-8-10-28-78)166-123(196)100(67-82-69-148-74-155-82)168-118(191)93(49-50-108(183)184)161-119(192)94(51-62-208-7)162-124(197)102(73-178)170-122(195)97(165-112(185)86(141)72-177)64-79-41-45-83(179)46-42-79/h8-12,27-30,41-48,68-69,74-77,86,88-105,109-111,152,177-180H,13-26,31-40,49-67,70-73,137-141H2,1-7H3,(H,148,155)(H,153,186)(H,154,200)(H,156,181)(H,157,182)(H,158,187)(H,159,188)(H,160,194)(H,161,192)(H,162,197)(H,163,201)(H,164,189)(H,165,185)(H,166,196)(H,167,190)(H,168,191)(H,169,202)(H,170,195)(H,171,193)(H,172,198)(H,173,199)(H,183,184)(H,206,207)(H4,142,143,149)(H4,144,145,150)(H4,146,147,151)/t86-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,109-,110-,111-/m0/s1

StdInChIKey

ZOEFCCMDUURGSE-SQKVDDBVSA-N

Molecular Formula

C136H210N40O31S

Molecular Weight

2933.5

EINECS

241-031-1

MDL Number

MFCD00167476

Properties

Appearance

White or yellow, amorphours powder

Safety Data

RIDADR

NONH for all modes of transport

WGK Germany

3

Specifications and Other Information of Our Tetracosactide Acetate CAS 16960-16-0

Standard

Enterprise standard

Identification Methods

HPLC

Assay(anhydrous and acetic acid –free substance)

90～102%

Identity by Amino Acids Analysis

Lys: 3.5~4.7
His:0.9~1.1
Arg: 2.7~3.3
Ser:1.1~2.2
Glu: 0.9~1.1
Pro: 2.5~3.5
Gly: 1.8~2.2
Met: 0.9~1.1
Tyr: 1.7~2.2
Phe:0.9~1.1

Specific Optical Rotation

-99.0～-109.0°(c=1，1%HAc)

Absorbance(0.2mg/ml 0.1M HCl)

Amax 276nm 0.51~0.61

Related Substance(By HPLC)

Total Impurities(%):≤9.0%
Any Single Impurity(%):≤2.5%

Acetate Content (By HPLC)

8.0~13.0%

Water Content(Karl Fischer)

≤14.0%

Bacterial Endotoxins

≤10IU/mg

Package

According to customer requirements to packaging

Storage

Store at 2-8℃，,Sealed and away from light

Application

For the diagnosis of adrenal insufficiency; also for the treatment of rheumatism, rheumatoid arthritis, skin diseases and shock.

Links

This product is sold exclusively through our sales company Watson International Ltd, and please click the link below for details.
http://www.watson-int.com/tetracosactide-acetate-cas-16960-16-0/